Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK2 [826-1132]' and Ligand = 'BDBM458879'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 [826-1132] (Homo sapiens (Human))	BDBM458879 (US10759793, Example 31) Show SMILES OC(=O)C1CCN(CC1)c1nc(nc(N[C@@H]2CCCN(C2)C(=O)CC#N)c1F)-c1cnn2ccccc12 Show InChI InChI=1S/C25H27FN8O3/c26-21-23(29-17-4-3-10-33(15-17)20(35)6-9-27)30-22(18-14-28-34-11-2-1-5-19(18)34)31-24(21)32-12-7-16(8-13-32)25(36)37/h1-2,5,11,14,16-17H,3-4,6-8,10,12-13,15H2,(H,36,37)(H,29,30,31)/t17-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Almirall, S.A. US Patent					Assay Description The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...				US Patent US10759793 (2020) BindingDB Entry DOI: 10.7270/Q2QC06MG
					More data for this Ligand-Target Pair