Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK3' and Ligand = 'BDBM113131'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM113131 (US8633206, 49) Show SMILES CN([C@H]1CC[C@H](CS(=O)(=O)N2CCC(CS(=O)(=O)CC3CC3)CC2)CC1)c1ncnc2[nH]ccc12 |r,wU:5.5,wD:2.1,(6.54,-2.21,;5.2,-2.98,;3.87,-2.21,;3.87,-.67,;2.53,.1,;1.2,-.67,;-.13,.1,;-1.47,-.67,;-1.47,-2.21,;-.13,-1.44,;-2.8,.1,;-2.8,1.64,;-4.13,2.41,;-5.47,1.64,;-6.8,2.41,;-6.8,3.95,;-5.47,4.72,;-5.47,3.18,;-8.14,4.72,;-8.14,6.26,;-7.37,7.6,;-8.91,7.6,;-5.47,.1,;-4.13,-.67,;1.2,-2.21,;2.53,-2.98,;5.2,-4.52,;3.87,-5.29,;3.87,-6.83,;5.2,-7.6,;6.54,-6.83,;8,-7.3,;8.91,-6.06,;8,-4.81,;6.54,-5.29,)| Show InChI InChI=1S/C24H37N5O4S2/c1-28(24-22-8-11-25-23(22)26-17-27-24)21-6-4-19(5-7-21)16-35(32,33)29-12-9-20(10-13-29)15-34(30,31)14-18-2-3-18/h8,11,17-21H,2-7,9-10,12-16H2,1H3,(H,25,26,27)/t19-,21-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	491	n/a	n/a	n/a	n/a	7.4	n/a
Pfizer Inc. US Patent					Assay Description A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...				US Patent US8633206 (2014) BindingDB Entry DOI: 10.7270/Q2ZS2V44
					More data for this Ligand-Target Pair