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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK3' and Ligand = 'BDBM487304'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM487304
PNG
(US10947254, Example 5-26)
Show SMILES Cc1cc(Nc2cc3nc(CN4CCOCC4)ccc3c(N[C@@H]3C[C@@H]4CCC[C@H](C3)N4CCC#N)n2)n[nH]1 |THB:31:30:27.26.25:22.29.23|
Show InChI InChI=1S/C28H37N9O/c1-19-14-27(35-34-19)32-26-17-25-24(7-6-20(30-25)18-36-10-12-38-13-11-36)28(33-26)31-21-15-22-4-2-5-23(16-21)37(22)9-3-8-29/h6-7,14,17,21-23H,2-5,9-13,15-16,18H2,1H3,(H3,31,32,33,34,35)/t21-,22+,23-
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US Patent
<0.100n/an/an/an/an/an/an/an/a



Theravance Biopharma R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...


US Patent US10947254 (2021)


BindingDB Entry DOI: 10.7270/Q2KH0RF0
More data for this
Ligand-Target Pair