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Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK3' and Ligand = 'BDBM50463807'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM50463807
PNG
(CHEMBL4248451)
Show SMILES COCCn1cc(cn1)-c1nn(C2CCN(CC2)C#N)c2ncnc(N)c12
Show InChI InChI=1S/C17H21N9O/c1-27-7-6-25-9-12(8-22-25)15-14-16(19)20-11-21-17(14)26(23-15)13-2-4-24(10-18)5-3-13/h8-9,11,13H,2-7H2,1H3,(H2,19,20,21)
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n/an/a 124n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human GST-tagged JAK3 catalytic domain expressed in baculovirus expression system using TK-substrate-biotin preincubated fo...

Bioorg Med Chem 26: 4774-4786 (2018)


Article DOI: 10.1016/j.bmc.2018.04.005
BindingDB Entry DOI: 10.7270/Q26Q20XK
More data for this
Ligand-Target Pair