Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK3' and Ligand = 'BDBM50466678'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50466678 (CHEMBL4288935) Show SMILES COCCS(=O)(=O)N[C@@H]1C[C@H](NC#N)c2cc(ccc12)-c1ncnc2[nH]ccc12 |r| Show InChI InChI=1S/C19H20N6O3S/c1-28-6-7-29(26,27)25-17-9-16(22-10-20)15-8-12(2-3-13(15)17)18-14-4-5-21-19(14)24-11-23-18/h2-5,8,11,16-17,22,25H,6-7,9H2,1H3,(H,21,23,24)/t16-,17+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant human GST-tagged JAK3 JH1 domain using KAIETDKEYYTVKD-NH2 as substrate in presence of ATP at Km concentration by coupled PK...				J Med Chem 61: 10665-10699 (2018) Article DOI: 10.1021/acs.jmedchem.8b01308 BindingDB Entry DOI: 10.7270/Q25T3P53
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50466678 (CHEMBL4288935) Show SMILES COCCS(=O)(=O)N[C@@H]1C[C@H](NC#N)c2cc(ccc12)-c1ncnc2[nH]ccc12 |r| Show InChI InChI=1S/C19H20N6O3S/c1-28-6-7-29(26,27)25-17-9-16(22-10-20)15-8-12(2-3-13(15)17)18-14-4-5-21-19(14)24-11-23-18/h2-5,8,11,16-17,22,25H,6-7,9H2,1H3,(H,21,23,24)/t16-,17+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	111	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant human GST-tagged JAK3 JH1 domain using KAIETDKEYYTVKD-NH2 as substrate in presence of 1 mM ATP concentration by coupled PK/...				J Med Chem 61: 10665-10699 (2018) Article DOI: 10.1021/acs.jmedchem.8b01308 BindingDB Entry DOI: 10.7270/Q25T3P53
					More data for this Ligand-Target Pair