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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK3' and Ligand = 'BDBM50533680'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM50533680
PNG
(CHEMBL4455068)
Show SMILES NC(=O)c1cnc(Nc2ccccn2)cc1NC1CCN(CC1)c1ccc(cn1)C#N
Show InChI InChI=1S/C22H22N8O/c23-12-15-4-5-21(27-13-15)30-9-6-16(7-10-30)28-18-11-20(26-14-17(18)22(24)31)29-19-3-1-2-8-25-19/h1-5,8,11,13-14,16H,6-7,9-10H2,(H2,24,31)(H2,25,26,28,29)
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PC cid
PC sid
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Article
PubMed
n/an/a 0.460n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of human JAK3 assessed as reduction in phosphorylation of Biotin-Lyn-Substrate-2 after 1 hr in presence of ATP by ELISA

Bioorg Med Chem 24: 4711-4722 (2016)


Article DOI: 10.1016/j.bmc.2016.08.007
BindingDB Entry DOI: 10.7270/Q2RJ4NZW
More data for this
Ligand-Target Pair