Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK3 [512-1124]' and Ligand = 'BDBM493279'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK3 [512-1124] (Homo sapiens (Human))	BDBM493279 (2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihyd...) Show SMILES O=C(Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)Nc1ccc(cc1)C#N |r,wU:18.21,wD:15.17,(-2.12,.28,;-1.35,1.61,;.19,1.61,;.96,.28,;.33,-1.13,;1.48,-2.16,;1.48,-3.7,;2.81,-4.47,;4.14,-3.7,;5.61,-4.18,;6.51,-2.93,;5.61,-1.69,;4.14,-2.16,;2.81,-1.39,;2.49,.12,;3.58,1.2,;5.07,.81,;6.16,1.89,;5.76,3.38,;6.85,4.47,;8.33,4.07,;9.82,3.67,;4.27,3.78,;3.18,2.69,;-2.12,2.94,;-3.66,2.94,;-4.43,4.28,;-5.97,4.28,;-6.74,2.94,;-5.97,1.61,;-4.43,1.61,;-8.28,2.94,;-9.82,2.94,)| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13.7	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description 11-point dosing series were made for each compound by serially diluting 1:3 or 1:4 in DMSO, with point 12 being a DMSO control. From the serial dilut...				US Patent US10981911 (2021) BindingDB Entry DOI: 10.7270/Q27P92G6
					More data for this Ligand-Target Pair