Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase Lck' and Ligand = 'BDBM340115'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340115 ((S)-4-(8-amino-3-(1-(N-methylbut- 2-ynamido)ethyl)...) Show SMILES CCCc1ccnc(NC(=O)c2ccc(cc2)-c2nc([C@H](C)N(C)C(=O)C#CC)n3ccnc(N)c23)c1 |r| Show InChI InChI=1S/C28H29N7O2/c1-5-7-19-13-14-30-22(17-19)32-28(37)21-11-9-20(10-12-21)24-25-26(29)31-15-16-35(25)27(33-24)18(3)34(4)23(36)8-6-2/h9-18H,5,7H2,1-4H3,(H2,29,31)(H,30,32,37)/t18-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US9758524 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DPQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340115 ((S)-4-(8-amino-3-(1-(N-methylbut- 2-ynamido)ethyl)...) Show SMILES CCCc1ccnc(NC(=O)c2ccc(cc2)-c2nc([C@H](C)N(C)C(=O)C#CC)n3ccnc(N)c23)c1 |r| Show InChI InChI=1S/C28H29N7O2/c1-5-7-19-13-14-30-22(17-19)32-28(37)21-11-9-20(10-12-21)24-25-26(29)31-15-16-35(25)27(33-24)18(3)34(4)23(36)8-6-2/h9-18H,5,7H2,1-4H3,(H2,29,31)(H,30,32,37)/t18-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340115 ((S)-4-(8-amino-3-(1-(N-methylbut- 2-ynamido)ethyl)...) Show SMILES CCCc1ccnc(NC(=O)c2ccc(cc2)-c2nc([C@H](C)N(C)C(=O)C#CC)n3ccnc(N)c23)c1 |r| Show InChI InChI=1S/C28H29N7O2/c1-5-7-19-13-14-30-22(17-19)32-28(37)21-11-9-20(10-12-21)24-25-26(29)31-15-16-35(25)27(33-24)18(3)34(4)23(36)8-6-2/h9-18H,5,7H2,1-4H3,(H2,29,31)(H,30,32,37)/t18-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Lck enzyme (Millipore catalog #14-442), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM ...				J Med Chem 48: 6169-73 (2005) BindingDB Entry DOI: 10.7270/Q20R9RQ4
					More data for this Ligand-Target Pair