Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase Mer' and Ligand = 'BDBM246979'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM246979 (4-{3-[2-(Aminomethyl)-2,3-dihydro-1H-inden-2-yl]ph...) Show SMILES CC(C)Nc1nc(-c2cccc(c2)C2(CN)Cc3ccccc3C2)c2cc[nH]c2n1 Show InChI InChI=1S/C25H27N5/c1-16(2)28-24-29-22(21-10-11-27-23(21)30-24)17-8-5-9-20(12-17)25(15-26)13-18-6-3-4-7-19(18)14-25/h3-12,16H,13-15,26H2,1-2H3,(H2,27,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	25
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10053465 (2018) BindingDB Entry DOI: 10.7270/Q2B27X98
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM246979 (4-{3-[2-(Aminomethyl)-2,3-dihydro-1H-inden-2-yl]ph...) Show SMILES CC(C)Nc1nc(-c2cccc(c2)C2(CN)Cc3ccccc3C2)c2cc[nH]c2n1 Show InChI InChI=1S/C25H27N5/c1-16(2)28-24-29-22(21-10-11-27-23(21)30-24)17-8-5-9-20(12-17)25(15-26)13-18-6-3-4-7-19(18)14-25/h3-12,16H,13-15,26H2,1-2H3,(H2,27,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2RJ4NMD
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM246979 (4-{3-[2-(Aminomethyl)-2,3-dihydro-1H-inden-2-yl]ph...) Show SMILES CC(C)Nc1nc(-c2cccc(c2)C2(CN)Cc3ccccc3C2)c2cc[nH]c2n1 Show InChI InChI=1S/C25H27N5/c1-16(2)28-24-29-22(21-10-11-27-23(21)30-24)17-8-5-9-20(12-17)25(15-26)13-18-6-3-4-7-19(18)14-25/h3-12,16H,13-15,26H2,1-2H3,(H2,27,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10519163 (2019) BindingDB Entry DOI: 10.7270/Q28K7CGF
					More data for this Ligand-Target Pair