Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase Mer' and Ligand = 'BDBM396952'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396952 (US10442810, Example 14 | US10844069, Example 14 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3)c12)C1CCOCC1 Show InChI InChI=1S/C29H25FN6O3/c30-20-5-9-22(10-6-20)35-13-1-2-23(29(35)38)28(37)34-21-7-3-18(4-8-21)24-16-25(19-11-14-39-15-12-19)36-26(24)27(31)32-17-33-36/h1-10,13,16-17,19H,11-12,14-15H2,(H,34,37)(H2,31,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396952 (US10442810, Example 14 | US10844069, Example 14 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3)c12)C1CCOCC1 Show InChI InChI=1S/C29H25FN6O3/c30-20-5-9-22(10-6-20)35-13-1-2-23(29(35)38)28(37)34-21-7-3-18(4-8-21)24-16-25(19-11-14-39-15-12-19)36-26(24)27(31)32-17-33-36/h1-10,13,16-17,19H,11-12,14-15H2,(H,34,37)(H2,31,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396952 (US10442810, Example 14 | US10844069, Example 14 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3)c12)C1CCOCC1 Show InChI InChI=1S/C29H25FN6O3/c30-20-5-9-22(10-6-20)35-13-1-2-23(29(35)38)28(37)34-21-7-3-18(4-8-21)24-16-25(19-11-14-39-15-12-19)36-26(24)27(31)32-17-33-36/h1-10,13,16-17,19H,11-12,14-15H2,(H,34,37)(H2,31,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396952 (US10442810, Example 14 | US10844069, Example 14 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3)c12)C1CCOCC1 Show InChI InChI=1S/C29H25FN6O3/c30-20-5-9-22(10-6-20)35-13-1-2-23(29(35)38)28(37)34-21-7-3-18(4-8-21)24-16-25(19-11-14-39-15-12-19)36-26(24)27(31)32-17-33-36/h1-10,13,16-17,19H,11-12,14-15H2,(H,34,37)(H2,31,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MW2N2P
					More data for this Ligand-Target Pair