Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase Mer' and Ligand = 'BDBM396972'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396972 (US10442810, Example 34 | US10844069, Example 34 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3F)c12)C1CCNCC1 Show InChI InChI=1S/C29H26FN7O2/c30-24-15-19(35-28(38)22-7-4-14-36(29(22)39)20-5-2-1-3-6-20)8-9-21(24)23-16-25(18-10-12-32-13-11-18)37-26(23)27(31)33-17-34-37/h1-9,14-18,32H,10-13H2,(H,35,38)(H2,31,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396972 (US10442810, Example 34 | US10844069, Example 34 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3F)c12)C1CCNCC1 Show InChI InChI=1S/C29H26FN7O2/c30-24-15-19(35-28(38)22-7-4-14-36(29(22)39)20-5-2-1-3-6-20)8-9-21(24)23-16-25(18-10-12-32-13-11-18)37-26(23)27(31)33-17-34-37/h1-9,14-18,32H,10-13H2,(H,35,38)(H2,31,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396972 (US10442810, Example 34 | US10844069, Example 34 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3F)c12)C1CCNCC1 Show InChI InChI=1S/C29H26FN7O2/c30-24-15-19(35-28(38)22-7-4-14-36(29(22)39)20-5-2-1-3-6-20)8-9-21(24)23-16-25(18-10-12-32-13-11-18)37-26(23)27(31)33-17-34-37/h1-9,14-18,32H,10-13H2,(H,35,38)(H2,31,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396972 (US10442810, Example 34 | US10844069, Example 34 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3F)c12)C1CCNCC1 Show InChI InChI=1S/C29H26FN7O2/c30-24-15-19(35-28(38)22-7-4-14-36(29(22)39)20-5-2-1-3-6-20)8-9-21(24)23-16-25(18-10-12-32-13-11-18)37-26(23)27(31)33-17-34-37/h1-9,14-18,32H,10-13H2,(H,35,38)(H2,31,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MW2N2P
					More data for this Ligand-Target Pair