Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase Mer' and Ligand = 'BDBM397000'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM397000 (US10442810, Example 62 | US10844069, Example 62 | ...) Show SMILES CCN(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4ccccc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C35H39N9O4/c1-5-40(4)34(47)41-17-15-24(16-18-41)29-19-27(30-31(36)37-21-38-44(29)30)23-11-13-25(14-12-23)39-32(45)28-20-42(22(2)3)35(48)43(33(28)46)26-9-7-6-8-10-26/h6-14,19-22,24H,5,15-18H2,1-4H3,(H,39,45)(H2,36,37,38)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM397000 (US10442810, Example 62 | US10844069, Example 62 | ...) Show SMILES CCN(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4ccccc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C35H39N9O4/c1-5-40(4)34(47)41-17-15-24(16-18-41)29-19-27(30-31(36)37-21-38-44(29)30)23-11-13-25(14-12-23)39-32(45)28-20-42(22(2)3)35(48)43(33(28)46)26-9-7-6-8-10-26/h6-14,19-22,24H,5,15-18H2,1-4H3,(H,39,45)(H2,36,37,38)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM397000 (US10442810, Example 62 | US10844069, Example 62 | ...) Show SMILES CCN(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4ccccc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C35H39N9O4/c1-5-40(4)34(47)41-17-15-24(16-18-41)29-19-27(30-31(36)37-21-38-44(29)30)23-11-13-25(14-12-23)39-32(45)28-20-42(22(2)3)35(48)43(33(28)46)26-9-7-6-8-10-26/h6-14,19-22,24H,5,15-18H2,1-4H3,(H,39,45)(H2,36,37,38)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM397000 (US10442810, Example 62 | US10844069, Example 62 | ...) Show SMILES CCN(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4ccccc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C35H39N9O4/c1-5-40(4)34(47)41-17-15-24(16-18-41)29-19-27(30-31(36)37-21-38-44(29)30)23-11-13-25(14-12-23)39-32(45)28-20-42(22(2)3)35(48)43(33(28)46)26-9-7-6-8-10-26/h6-14,19-22,24H,5,15-18H2,1-4H3,(H,39,45)(H2,36,37,38)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MW2N2P
					More data for this Ligand-Target Pair