Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase Mer' and Ligand = 'BDBM397005'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM397005 (US10442810, Example 67 | US10844069, Example 67 | ...) Show SMILES CCn1cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C(=O)N(C)C)n3ncnc(N)c23)c(=O)n(-c2ccc(F)cc2)c1=O Show InChI InChI=1S/C33H34FN9O4/c1-4-40-18-26(31(45)42(33(40)47)24-11-7-22(34)8-12-24)30(44)38-23-9-5-20(6-10-23)25-17-27(43-28(25)29(35)36-19-37-43)21-13-15-41(16-14-21)32(46)39(2)3/h5-12,17-19,21H,4,13-16H2,1-3H3,(H,38,44)(H2,35,36,37)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM397005 (US10442810, Example 67 | US10844069, Example 67 | ...) Show SMILES CCn1cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C(=O)N(C)C)n3ncnc(N)c23)c(=O)n(-c2ccc(F)cc2)c1=O Show InChI InChI=1S/C33H34FN9O4/c1-4-40-18-26(31(45)42(33(40)47)24-11-7-22(34)8-12-24)30(44)38-23-9-5-20(6-10-23)25-17-27(43-28(25)29(35)36-19-37-43)21-13-15-41(16-14-21)32(46)39(2)3/h5-12,17-19,21H,4,13-16H2,1-3H3,(H,38,44)(H2,35,36,37)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM397005 (US10442810, Example 67 | US10844069, Example 67 | ...) Show SMILES CCn1cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C(=O)N(C)C)n3ncnc(N)c23)c(=O)n(-c2ccc(F)cc2)c1=O Show InChI InChI=1S/C33H34FN9O4/c1-4-40-18-26(31(45)42(33(40)47)24-11-7-22(34)8-12-24)30(44)38-23-9-5-20(6-10-23)25-17-27(43-28(25)29(35)36-19-37-43)21-13-15-41(16-14-21)32(46)39(2)3/h5-12,17-19,21H,4,13-16H2,1-3H3,(H,38,44)(H2,35,36,37)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM397005 (US10442810, Example 67 | US10844069, Example 67 | ...) Show SMILES CCn1cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C(=O)N(C)C)n3ncnc(N)c23)c(=O)n(-c2ccc(F)cc2)c1=O Show InChI InChI=1S/C33H34FN9O4/c1-4-40-18-26(31(45)42(33(40)47)24-11-7-22(34)8-12-24)30(44)38-23-9-5-20(6-10-23)25-17-27(43-28(25)29(35)36-19-37-43)21-13-15-41(16-14-21)32(46)39(2)3/h5-12,17-19,21H,4,13-16H2,1-3H3,(H,38,44)(H2,35,36,37)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MW2N2P
					More data for this Ligand-Target Pair