Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM127992'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM127992 (US8796310, 21) Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1cnc(s1)C1(O)CCCc2cc(ccc12)-c1nnn[nH]1 Show InChI InChI=1S/C26H21F3N8OS/c1-14-9-19(32-22(10-14)33-21-12-17(6-8-30-21)26(27,28)29)20-13-31-24(39-20)25(38)7-2-3-15-11-16(4-5-18(15)25)23-34-36-37-35-23/h4-6,8-13,38H,2-3,7H2,1H3,(H,30,32,33)(H,34,35,36,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.680	n/a	n/a	n/a	n/a	7.5	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Cama Bio...				US Patent US8796310 (2014) BindingDB Entry DOI: 10.7270/Q29W0D61
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