Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM128016'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM128016 (US8796310, 1M) Show SMILES CCCc1ccnc(Nc2cc(C)cc(n2)-c2cnc(s2)C2(O)CCCc3cc(ccc23)C(O)=O)c1 Show InChI InChI=1S/C28H28N4O3S/c1-3-5-18-9-11-29-24(14-18)32-25-13-17(2)12-22(31-25)23-16-30-27(36-23)28(35)10-4-6-19-15-20(26(33)34)7-8-21(19)28/h7-9,11-16,35H,3-6,10H2,1-2H3,(H,33,34)(H,29,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<0.5	n/a	n/a	n/a	n/a	7.5	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Cama Bio...				US Patent US8796310 (2014) BindingDB Entry DOI: 10.7270/Q29W0D61
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