Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM177761'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM177761 (US9120785, Example 2 racemic mixture) Show SMILES CCC(O)([C@H]1CC[C@@H](CC1)C(N)=O)c1ncc(s1)-c1cc(C)cc(Nc2cc(ccn2)C2CC2)n1 |r,wU:7.10,wD:4.3,(1.97,13.6,;1.97,15.14,;.64,15.91,;1.41,17.25,;2.18,15.91,;2.95,14.58,;4.49,14.58,;5.26,15.91,;4.49,17.25,;2.95,17.25,;6.8,15.91,;7.57,14.58,;7.57,17.25,;-.13,14.58,;-1.67,14.58,;-2.15,13.11,;-.9,12.21,;.35,13.11,;-.9,10.67,;.43,9.9,;.48,8.33,;1.81,7.56,;-.9,7.59,;-2.23,8.36,;-3.57,7.59,;-4.9,8.36,;-4.9,9.9,;-6.24,10.67,;-7.57,9.9,;-7.57,8.36,;-6.24,7.59,;-6.24,12.21,;-5.47,13.54,;-7.01,13.54,;-2.23,9.9,)| Show InChI InChI=1S/C27H33N5O2S/c1-3-27(34,20-8-6-18(7-9-20)25(28)33)26-30-15-22(35-26)21-12-16(2)13-24(31-21)32-23-14-19(10-11-29-23)17-4-5-17/h10-15,17-18,20,34H,3-9H2,1-2H3,(H2,28,33)(H,29,31,32)/t18-,20-,27?	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.10	n/a	n/a	n/a	n/a	7.5	25
Merck Sharp & Dohme Corp. US Patent					Assay Description Homogeneous Time-Resolved Fluorescence (HTRF) assay for the recombinant human Syk enzyme: A recombinant GST-hSyk fusion protein was used to measure p...				US Patent US9120785 (2015) BindingDB Entry DOI: 10.7270/Q2959G9C
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