Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM177762'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM177762 (US9120785, Example 9 Enantiomer 1) Show SMILES CCCCOC(=O)[C@H]1CC[C@@H](CC1)[C@@](C)(O)c1ncc(s1)-c1cc(C)cc(Nc2cc(C)c(F)cn2)n1 |r,wU:13.14,7.6,wD:13.15,10.10,(8.57,19.44,;7.08,19.84,;5.99,18.75,;4.51,19.15,;3.42,18.06,;1.93,18.46,;1.53,19.95,;.84,17.37,;1.24,15.88,;.15,14.79,;-1.34,15.19,;-1.74,16.68,;-.65,17.77,;-2.11,13.86,;-3.44,14.63,;-3.44,13.09,;-1.34,12.53,;.2,12.53,;.68,11.06,;-.57,10.16,;-1.81,11.06,;-.57,8.62,;.77,7.85,;.77,6.31,;2.1,5.54,;-.57,5.54,;-1.9,6.31,;-3.23,5.54,;-4.57,6.31,;-4.57,7.85,;-5.9,8.62,;-5.9,10.16,;-7.24,7.85,;-8.57,8.62,;-7.24,6.31,;-5.9,5.54,;-1.9,7.85,)| Show InChI InChI=1S/C28H35FN4O3S/c1-5-6-11-36-26(34)19-7-9-20(10-8-19)28(4,35)27-31-16-23(37-27)22-12-17(2)13-25(32-22)33-24-14-18(3)21(29)15-30-24/h12-16,19-20,35H,5-11H2,1-4H3,(H,30,32,33)/t19-,20-,28-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	278	n/a	n/a	n/a	n/a	7.5	25
Merck Sharp & Dohme Corp. US Patent					Assay Description Homogeneous Time-Resolved Fluorescence (HTRF) assay for the recombinant human Syk enzyme: A recombinant GST-hSyk fusion protein was used to measure p...				US Patent US9120785 (2015) BindingDB Entry DOI: 10.7270/Q2959G9C
					More data for this Ligand-Target Pair