Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM177765'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM177765 (US9120785, Example 14 Step 2) Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1cnc(s1)C(C)(O)[C@H]1CC[C@@H](CC1)C(O)=O |r,wU:29.35,wD:26.28,(1.87,-4.83,;.54,-4.06,;-.8,-4.83,;-2.13,-4.06,;-3.47,-4.83,;-4.8,-4.06,;-4.8,-2.52,;-6.13,-1.69,;-7.47,-2.52,;-7.47,-4.06,;-6.13,-4.83,;-6.13,-.15,;-6.13,1.39,;-4.59,-.15,;-7.67,-.15,;-2.13,-2.52,;-.8,-1.75,;.54,-2.52,;-.8,-.21,;-2.04,.7,;-1.57,2.16,;-.03,2.16,;.45,.7,;.74,3.49,;-.03,4.83,;1.51,4.83,;2.28,3.49,;3.05,2.16,;4.59,2.16,;5.36,3.49,;4.59,4.83,;3.05,4.83,;6.9,3.49,;7.67,2.16,;7.67,4.83,)| Show InChI InChI=1S/C24H25F3N4O3S/c1-13-9-17(30-20(10-13)31-19-11-16(7-8-28-19)24(25,26)27)18-12-29-22(35-18)23(2,34)15-5-3-14(4-6-15)21(32)33/h7-12,14-15,34H,3-6H2,1-2H3,(H,32,33)(H,28,30,31)/t14-,15-,23?	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	7.5	25
Merck Sharp & Dohme Corp. US Patent					Assay Description Homogeneous Time-Resolved Fluorescence (HTRF) assay for the recombinant human Syk enzyme: A recombinant GST-hSyk fusion protein was used to measure p...				US Patent US9120785 (2015) BindingDB Entry DOI: 10.7270/Q2959G9C
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