Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM177766'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM177766 (US9120785, Example 14-2) Show SMILES CCCCOC(=O)C1CCC(CC1)C(C)(O)c1ncc(s1)-c1cc(C)cc(Nc2cc(OC)ccn2)n1 |(5.83,5.23,;5.06,3.9,;3.52,3.9,;2.75,2.56,;1.21,2.56,;.44,1.23,;1.21,-.1,;-1.1,1.23,;-1.93,-.1,;-3.47,-.1,;-4.23,1.23,;-3.47,2.56,;-1.93,2.56,;-5.78,1.23,;-6.86,2.32,;-5.01,2.56,;-6.55,-.1,;-8.09,-.1,;-8.56,-1.57,;-7.32,-2.47,;-6.07,-1.57,;-7.32,-4.01,;-5.98,-4.78,;-5.98,-6.32,;-4.65,-7.09,;-7.32,-7.09,;-8.65,-6.32,;-9.98,-7.09,;-11.32,-6.32,;-11.32,-4.78,;-12.65,-3.96,;-12.65,-2.42,;-13.98,-1.65,;-13.98,-4.78,;-13.98,-6.32,;-12.65,-7.09,;-8.65,-4.78,)| Show InChI InChI=1S/C28H36N4O4S/c1-5-6-13-36-26(33)19-7-9-20(10-8-19)28(3,34)27-30-17-23(37-27)22-14-18(2)15-25(31-22)32-24-16-21(35-4)11-12-29-24/h11-12,14-17,19-20,34H,5-10,13H2,1-4H3,(H,29,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	219	n/a	n/a	n/a	n/a	7.5	25
Merck Sharp & Dohme Corp. US Patent					Assay Description Homogeneous Time-Resolved Fluorescence (HTRF) assay for the recombinant human Syk enzyme: A recombinant GST-hSyk fusion protein was used to measure p...				US Patent US9120785 (2015) BindingDB Entry DOI: 10.7270/Q2959G9C
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