Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM177769'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM177769 (US9120785, Example 14-15) Show SMILES CCC(O)(C1CCC(CC1)C(O)=O)c1ncc(s1)-c1cc(C)cc(Nc2cc(ccn2)C(F)(F)F)n1 |(-6.13,,;-4.8,.77,;-3.47,,;-2.7,1.33,;-1.93,,;-1.15,-1.33,;.38,-1.33,;1.21,,;.38,1.33,;-1.15,1.33,;2.75,0,;3.52,-1.33,;3.52,1.33,;-4.24,-1.33,;-5.78,-1.33,;-6.25,-2.8,;-5.01,-3.7,;-3.76,-2.8,;-5.01,-5.24,;-3.67,-6.01,;-3.67,-7.55,;-2.34,-8.32,;-5.01,-8.32,;-6.34,-7.55,;-7.67,-8.32,;-9.01,-7.55,;-9.01,-6.01,;-10.34,-5.19,;-11.67,-6.01,;-11.67,-7.55,;-10.34,-8.32,;-10.34,-3.65,;-11.67,-2.88,;-10.34,-2.11,;-9.01,-2.88,;-6.34,-6.01,)| Show InChI InChI=1S/C25H27F3N4O3S/c1-3-24(35,16-6-4-15(5-7-16)22(33)34)23-30-13-19(36-23)18-10-14(2)11-21(31-18)32-20-12-17(8-9-29-20)25(26,27)28/h8-13,15-16,35H,3-7H2,1-2H3,(H,33,34)(H,29,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	7.5	25
Merck Sharp & Dohme Corp. US Patent					Assay Description Homogeneous Time-Resolved Fluorescence (HTRF) assay for the recombinant human Syk enzyme: A recombinant GST-hSyk fusion protein was used to measure p...				US Patent US9120785 (2015) BindingDB Entry DOI: 10.7270/Q2959G9C
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