Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM302004'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302004 (US9598405, 2.3) Show SMILES Cc1cc(Nc2cc(OCCCNC(=O)OC(C)(C)C)ccn2)nc(c1)-c1cnc(s1)C1(O)CCC(CC1)C(O)=O |(25.24,-4.59,;26.58,-5.36,;26.58,-6.9,;27.91,-7.67,;27.91,-9.21,;26.58,-9.98,;25.24,-9.21,;23.91,-9.98,;22.57,-9.21,;21.24,-9.98,;19.91,-9.21,;18.57,-9.98,;17.24,-9.21,;15.91,-9.98,;15.91,-11.52,;14.57,-9.21,;13.24,-9.98,;11.91,-10.75,;14.01,-11.31,;12.47,-8.65,;23.91,-11.52,;25.24,-12.29,;26.58,-11.52,;29.24,-6.9,;29.24,-5.36,;27.91,-4.59,;30.58,-4.59,;30.74,-3.06,;32.24,-2.74,;33.01,-4.07,;31.98,-5.22,;34.55,-4.23,;34.44,-2.7,;36.04,-3.86,;37.11,-4.97,;36.68,-6.45,;35.19,-6.82,;34.12,-5.71,;37.75,-7.56,;37.33,-9.04,;39.25,-7.18,)| Show InChI InChI=1S/C29H37N5O6S/c1-18-14-21(22-17-32-26(41-22)29(38)9-6-19(7-10-29)25(35)36)33-24(15-18)34-23-16-20(8-12-30-23)39-13-5-11-31-27(37)40-28(2,3)4/h8,12,14-17,19,38H,5-7,9-11,13H2,1-4H3,(H,31,37)(H,35,36)(H,30,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	23.9	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
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