Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM381081'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM381081 (US9890185, Example 38(d)) Show SMILES COc1c(CC(N)=O)cc(cc1NC(=O)Nc1ccc(Oc2ccnc(NCc3ccccn3)c2)c2ccccc12)C(C)(C)C Show InChI InChI=1S/C35H36N6O4/c1-35(2,3)23-17-22(18-31(36)42)33(44-4)29(19-23)41-34(43)40-28-12-13-30(27-11-6-5-10-26(27)28)45-25-14-16-38-32(20-25)39-21-24-9-7-8-15-37-24/h5-17,19-20H,18,21H2,1-4H3,(H2,36,42)(H,38,39)(H2,40,41,43)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.65E+3	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon					Assay Description Method 2: The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashion to t...				J Med Chem 51: 5680-9 (2008) BindingDB Entry DOI: 10.7270/Q2FB558N
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