Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM50007100'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50007100 (CHEMBL3237569 | US10112928, Compound I-4) Show SMILES Cc1cccc(Nc2cc(Oc3cccc(F)c3)nnc2C(N)=O)n1 Show InChI InChI=1S/C17H14FN5O2/c1-10-4-2-7-14(20-10)21-13-9-15(22-23-16(13)17(19)24)25-12-6-3-5-11(18)8-12/h2-9H,1H3,(H2,19,24)(H,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	631	n/a	n/a	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. Curated by ChEMBL					Assay Description Inhibition of human SYK (360 to 635) using biotin-EPEGDYEEVLE as substrate preincubated for 10 mins followed by substrate/ATP/[33Pgamma]ATP addition ...				J Med Chem 57: 2683-91 (2014) Article DOI: 10.1021/jm401982j BindingDB Entry DOI: 10.7270/Q2HT2QTR
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