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Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK [342-635]' and Ligand = 'BDBM311116'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM311116
PNG
(US10155751, Example 3)
Show SMILES C[C@@H](Oc1nc(cc2nn(C)c(C)c12)-c1cnn(c1)C(C)(C)C)[C@H]1CNC(=O)O1 |r|
Show InChI InChI=1S/C20H26N6O3/c1-11-17-15(24-25(11)6)7-14(13-8-22-26(10-13)20(3,4)5)23-18(17)28-12(2)16-9-21-19(27)29-16/h7-8,10,12,16H,9H2,1-6H3,(H,21,27)/t12-,16-/m1/s1
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human SYK (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag. The test compounds were dissolved in 100% D...

US Patent US10155751 (2018)


BindingDB Entry DOI: 10.7270/Q2PK0J60
More data for this
Ligand-Target Pair