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Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK [342-635]' and Ligand = 'BDBM311120'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM311120
PNG
(US10155751, Example 7)
Show SMILES C[C@@H](Oc1cc(cc2nn(C)c(F)c12)-c1cnn(c1)C1CCC(F)(F)C1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C22H24F3N5O2/c1-12(14-7-19(31)26-9-14)32-18-6-13(5-17-20(18)21(23)29(2)28-17)15-10-27-30(11-15)16-3-4-22(24,25)8-16/h5-6,10-12,14,16H,3-4,7-9H2,1-2H3,(H,26,31)/t12-,14-,16?/m1/s1
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 1.30n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human SYK (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag. The test compounds were dissolved in 100% D...

US Patent US10155751 (2018)


BindingDB Entry DOI: 10.7270/Q2PK0J60
More data for this
Ligand-Target Pair