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Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK [342-635]' and Ligand = 'BDBM311125'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM311125
PNG
(US10155751, Example 12)
Show SMILES C[C@@H](Oc1cc(cc2nn(C)c(F)c12)-c1cnn(CCC(F)(F)F)c1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C20H21F4N5O2/c1-11(13-7-17(30)25-8-13)31-16-6-12(5-15-18(16)19(21)28(2)27-15)14-9-26-29(10-14)4-3-20(22,23)24/h5-6,9-11,13H,3-4,7-8H2,1-2H3,(H,25,30)/t11-,13-/m1/s1
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 2.90n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human SYK (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag. The test compounds were dissolved in 100% D...

US Patent US10155751 (2018)


BindingDB Entry DOI: 10.7270/Q2PK0J60
More data for this
Ligand-Target Pair