Found 4 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase receptor TYRO3' and Ligand = 'BDBM396966' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM396966
(N-{4-[4-Amino-7-(cis-4-cyanocyclohexyl)pyrrolo[2,1...)Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3)c12)[C@@H]1CC[C@@H](CC1)C#N |r,wU:32.36,35.43,(-5.98,13.04,;-6.45,11.58,;-7.96,11.26,;-8.44,9.79,;-7.41,8.65,;-5.9,8.97,;-4.65,8.06,;-3.41,8.97,;-3.88,10.43,;-3.11,11.76,;-1.57,11.76,;-.8,13.1,;-1.57,14.43,;-.8,15.77,;.74,15.77,;1.51,14.43,;1.51,17.1,;.74,18.43,;1.51,19.77,;3.05,19.77,;3.82,18.43,;5.36,18.43,;6.13,17.1,;7.67,17.1,;8.44,18.43,;7.67,19.77,;6.13,19.77,;3.05,17.1,;3.82,15.77,;-3.11,14.43,;-3.88,13.1,;-5.42,10.43,;-4.65,6.52,;-5.99,5.75,;-5.99,4.21,;-4.65,3.44,;-3.32,4.21,;-3.32,5.75,;-4.65,1.9,;-4.65,.36,)| Show InChI InChI=1S/C31H27N7O2/c32-18-20-8-10-22(11-9-20)27-17-26(28-29(33)34-19-35-38(27)28)21-12-14-23(15-13-21)36-30(39)25-7-4-16-37(31(25)40)24-5-2-1-3-6-24/h1-7,12-17,19-20,22H,8-11H2,(H,36,39)(H2,33,34,35)/t20-,22+ | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2MW2N2P |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM396966
(N-{4-[4-Amino-7-(cis-4-cyanocyclohexyl)pyrrolo[2,1...)Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3)c12)[C@@H]1CC[C@@H](CC1)C#N |r,wU:32.36,35.43,(-5.98,13.04,;-6.45,11.58,;-7.96,11.26,;-8.44,9.79,;-7.41,8.65,;-5.9,8.97,;-4.65,8.06,;-3.41,8.97,;-3.88,10.43,;-3.11,11.76,;-1.57,11.76,;-.8,13.1,;-1.57,14.43,;-.8,15.77,;.74,15.77,;1.51,14.43,;1.51,17.1,;.74,18.43,;1.51,19.77,;3.05,19.77,;3.82,18.43,;5.36,18.43,;6.13,17.1,;7.67,17.1,;8.44,18.43,;7.67,19.77,;6.13,19.77,;3.05,17.1,;3.82,15.77,;-3.11,14.43,;-3.88,13.1,;-5.42,10.43,;-4.65,6.52,;-5.99,5.75,;-5.99,4.21,;-4.65,3.44,;-3.32,4.21,;-3.32,5.75,;-4.65,1.9,;-4.65,.36,)| Show InChI InChI=1S/C31H27N7O2/c32-18-20-8-10-22(11-9-20)27-17-26(28-29(33)34-19-35-38(27)28)21-12-14-23(15-13-21)36-30(39)25-7-4-16-37(31(25)40)24-5-2-1-3-6-24/h1-7,12-17,19-20,22H,8-11H2,(H,36,39)(H2,33,34,35)/t20-,22+ | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >100 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
US Patent
| Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ... |
US Patent US10844069 (2020)
BindingDB Entry DOI: 10.7270/Q2CZ3B73 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM396966
(N-{4-[4-Amino-7-(cis-4-cyanocyclohexyl)pyrrolo[2,1...)Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3)c12)[C@@H]1CC[C@@H](CC1)C#N |r,wU:32.36,35.43,(-5.98,13.04,;-6.45,11.58,;-7.96,11.26,;-8.44,9.79,;-7.41,8.65,;-5.9,8.97,;-4.65,8.06,;-3.41,8.97,;-3.88,10.43,;-3.11,11.76,;-1.57,11.76,;-.8,13.1,;-1.57,14.43,;-.8,15.77,;.74,15.77,;1.51,14.43,;1.51,17.1,;.74,18.43,;1.51,19.77,;3.05,19.77,;3.82,18.43,;5.36,18.43,;6.13,17.1,;7.67,17.1,;8.44,18.43,;7.67,19.77,;6.13,19.77,;3.05,17.1,;3.82,15.77,;-3.11,14.43,;-3.88,13.1,;-5.42,10.43,;-4.65,6.52,;-5.99,5.75,;-5.99,4.21,;-4.65,3.44,;-3.32,4.21,;-3.32,5.75,;-4.65,1.9,;-4.65,.36,)| Show InChI InChI=1S/C31H27N7O2/c32-18-20-8-10-22(11-9-20)27-17-26(28-29(33)34-19-35-38(27)28)21-12-14-23(15-13-21)36-30(39)25-7-4-16-37(31(25)40)24-5-2-1-3-6-24/h1-7,12-17,19-20,22H,8-11H2,(H,36,39)(H2,33,34,35)/t20-,22+ | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >100 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description
Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve... |
J Med Chem 52: 3576-85 (2009)
BindingDB Entry DOI: 10.7270/Q2FB5593 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM396966
(N-{4-[4-Amino-7-(cis-4-cyanocyclohexyl)pyrrolo[2,1...)Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3)c12)[C@@H]1CC[C@@H](CC1)C#N |r,wU:32.36,35.43,(-5.98,13.04,;-6.45,11.58,;-7.96,11.26,;-8.44,9.79,;-7.41,8.65,;-5.9,8.97,;-4.65,8.06,;-3.41,8.97,;-3.88,10.43,;-3.11,11.76,;-1.57,11.76,;-.8,13.1,;-1.57,14.43,;-.8,15.77,;.74,15.77,;1.51,14.43,;1.51,17.1,;.74,18.43,;1.51,19.77,;3.05,19.77,;3.82,18.43,;5.36,18.43,;6.13,17.1,;7.67,17.1,;8.44,18.43,;7.67,19.77,;6.13,19.77,;3.05,17.1,;3.82,15.77,;-3.11,14.43,;-3.88,13.1,;-5.42,10.43,;-4.65,6.52,;-5.99,5.75,;-5.99,4.21,;-4.65,3.44,;-3.32,4.21,;-3.32,5.75,;-4.65,1.9,;-4.65,.36,)| Show InChI InChI=1S/C31H27N7O2/c32-18-20-8-10-22(11-9-20)27-17-26(28-29(33)34-19-35-38(27)28)21-12-14-23(15-13-21)36-30(39)25-7-4-16-37(31(25)40)24-5-2-1-3-6-24/h1-7,12-17,19-20,22H,8-11H2,(H,36,39)(H2,33,34,35)/t20-,22+ | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >100 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
US Patent
| Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ... |
US Patent US10442810 (2019)
BindingDB Entry DOI: 10.7270/Q2NG4T17 |
More data for this
Ligand-Target Pair | |
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