Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase receptor TYRO3' and Ligand = 'BDBM396994'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM396994 (US10442810, Example 56 | US10844069, Example 56 | ...) Show SMILES CCN(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C33H33FN8O3/c1-3-39(2)33(45)40-17-14-22(15-18-40)28-19-27(29-30(35)36-20-37-42(28)29)21-6-10-24(11-7-21)38-31(43)26-5-4-16-41(32(26)44)25-12-8-23(34)9-13-25/h4-13,16,19-20,22H,3,14-15,17-18H2,1-2H3,(H,38,43)(H2,35,36,37)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MW2N2P
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM396994 (US10442810, Example 56 | US10844069, Example 56 | ...) Show SMILES CCN(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C33H33FN8O3/c1-3-39(2)33(45)40-17-14-22(15-18-40)28-19-27(29-30(35)36-20-37-42(28)29)21-6-10-24(11-7-21)38-31(43)26-5-4-16-41(32(26)44)25-12-8-23(34)9-13-25/h4-13,16,19-20,22H,3,14-15,17-18H2,1-2H3,(H,38,43)(H2,35,36,37)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM396994 (US10442810, Example 56 | US10844069, Example 56 | ...) Show SMILES CCN(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C33H33FN8O3/c1-3-39(2)33(45)40-17-14-22(15-18-40)28-19-27(29-30(35)36-20-37-42(28)29)21-6-10-24(11-7-21)38-31(43)26-5-4-16-41(32(26)44)25-12-8-23(34)9-13-25/h4-13,16,19-20,22H,3,14-15,17-18H2,1-2H3,(H,38,43)(H2,35,36,37)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM396994 (US10442810, Example 56 | US10844069, Example 56 | ...) Show SMILES CCN(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C33H33FN8O3/c1-3-39(2)33(45)40-17-14-22(15-18-40)28-19-27(29-30(35)36-20-37-42(28)29)21-6-10-24(11-7-21)38-31(43)26-5-4-16-41(32(26)44)25-12-8-23(34)9-13-25/h4-13,16,19-20,22H,3,14-15,17-18H2,1-2H3,(H,38,43)(H2,35,36,37)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair