Compile Data Set for Download or QSAR

Found 6 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase receptor TYRO3' and Ligand = 'BDBM397021'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM397021 (US10442810, Example 83 | US10844069, Example 83 | ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4ccccn4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C34H37N9O4/c1-20(2)32(45)40-15-12-23(13-16-40)27-17-25(29-30(35)37-19-38-43(27)29)22-8-10-24(11-9-22)39-31(44)26-18-41(21(3)4)34(47)42(33(26)46)28-7-5-6-14-36-28/h5-11,14,17-21,23H,12-13,15-16H2,1-4H3,(H,39,44)(H2,35,37,38)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MW2N2P
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM397021 (US10442810, Example 83 | US10844069, Example 83 | ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4ccccn4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C34H37N9O4/c1-20(2)32(45)40-15-12-23(13-16-40)27-17-25(29-30(35)37-19-38-43(27)29)22-8-10-24(11-9-22)39-31(44)26-18-41(21(3)4)34(47)42(33(26)46)28-7-5-6-14-36-28/h5-11,14,17-21,23H,12-13,15-16H2,1-4H3,(H,39,44)(H2,35,37,38)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				Citation and Details BindingDB Entry DOI: 10.7270/Q23F4SSC
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM397021 (US10442810, Example 83 | US10844069, Example 83 | ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4ccccn4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C34H37N9O4/c1-20(2)32(45)40-15-12-23(13-16-40)27-17-25(29-30(35)37-19-38-43(27)29)22-8-10-24(11-9-22)39-31(44)26-18-41(21(3)4)34(47)42(33(26)46)28-7-5-6-14-36-28/h5-11,14,17-21,23H,12-13,15-16H2,1-4H3,(H,39,44)(H2,35,37,38)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T8F
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM397021 (US10442810, Example 83 | US10844069, Example 83 | ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4ccccn4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C34H37N9O4/c1-20(2)32(45)40-15-12-23(13-16-40)27-17-25(29-30(35)37-19-38-43(27)29)22-8-10-24(11-9-22)39-31(44)26-18-41(21(3)4)34(47)42(33(26)46)28-7-5-6-14-36-28/h5-11,14,17-21,23H,12-13,15-16H2,1-4H3,(H,39,44)(H2,35,37,38)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM397021 (US10442810, Example 83 | US10844069, Example 83 | ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4ccccn4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C34H37N9O4/c1-20(2)32(45)40-15-12-23(13-16-40)27-17-25(29-30(35)37-19-38-43(27)29)22-8-10-24(11-9-22)39-31(44)26-18-41(21(3)4)34(47)42(33(26)46)28-7-5-6-14-36-28/h5-11,14,17-21,23H,12-13,15-16H2,1-4H3,(H,39,44)(H2,35,37,38)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM397021 (US10442810, Example 83 | US10844069, Example 83 | ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4ccccn4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C34H37N9O4/c1-20(2)32(45)40-15-12-23(13-16-40)27-17-25(29-30(35)37-19-38-43(27)29)22-8-10-24(11-9-22)39-31(44)26-18-41(21(3)4)34(47)42(33(26)46)28-7-5-6-14-36-28/h5-11,14,17-21,23H,12-13,15-16H2,1-4H3,(H,39,44)(H2,35,37,38)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair