Found 4 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase receptor TYRO3' and Ligand = 'BDBM397022' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM397022
(US10442810, Example 84 | US10844069, Example 84 | ...)Show SMILES CC(C)n1cc(C(=O)Nc2ccc(cc2)-c2cc(-c3c(C)nn(C)c3C)n3ncnc(N)c23)c(=O)n(-c2cccc(F)c2)c1=O |(6.04,5.15,;4.95,6.24,;5.35,7.73,;3.46,5.84,;3.06,4.35,;1.57,3.96,;1.18,2.47,;2.27,1.38,;-.31,2.07,;-.71,.58,;.38,-.51,;-.02,-1.99,;-1.51,-2.39,;-2.6,-1.3,;-2.2,.18,;-1.91,-3.88,;-1,-5.13,;-1.91,-6.37,;-1.51,-7.86,;-.04,-8.34,;1.29,-7.57,;-.04,-9.88,;-1.51,-10.35,;-2.28,-11.69,;-2.41,-9.11,;-3.95,-9.11,;-3.37,-5.9,;-4.7,-6.67,;-6.04,-5.9,;-6.04,-4.36,;-4.7,-3.59,;-4.7,-2.05,;-3.37,-4.36,;.49,5.04,;-1,4.65,;.88,6.53,;-.2,7.62,;-1.69,7.22,;-2.78,8.31,;-2.38,9.8,;-.89,10.2,;-.5,11.69,;.19,9.11,;2.37,6.93,;2.77,8.42,)| Show InChI InChI=1S/C32H30FN9O3/c1-17(2)40-15-25(31(44)41(32(40)45)23-8-6-7-21(33)13-23)30(43)37-22-11-9-20(10-12-22)24-14-26(27-18(3)38-39(5)19(27)4)42-28(24)29(34)35-16-36-42/h6-17H,1-5H3,(H,37,43)(H2,34,35,36) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2MW2N2P |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM397022
(US10442810, Example 84 | US10844069, Example 84 | ...)Show SMILES CC(C)n1cc(C(=O)Nc2ccc(cc2)-c2cc(-c3c(C)nn(C)c3C)n3ncnc(N)c23)c(=O)n(-c2cccc(F)c2)c1=O |(6.04,5.15,;4.95,6.24,;5.35,7.73,;3.46,5.84,;3.06,4.35,;1.57,3.96,;1.18,2.47,;2.27,1.38,;-.31,2.07,;-.71,.58,;.38,-.51,;-.02,-1.99,;-1.51,-2.39,;-2.6,-1.3,;-2.2,.18,;-1.91,-3.88,;-1,-5.13,;-1.91,-6.37,;-1.51,-7.86,;-.04,-8.34,;1.29,-7.57,;-.04,-9.88,;-1.51,-10.35,;-2.28,-11.69,;-2.41,-9.11,;-3.95,-9.11,;-3.37,-5.9,;-4.7,-6.67,;-6.04,-5.9,;-6.04,-4.36,;-4.7,-3.59,;-4.7,-2.05,;-3.37,-4.36,;.49,5.04,;-1,4.65,;.88,6.53,;-.2,7.62,;-1.69,7.22,;-2.78,8.31,;-2.38,9.8,;-.89,10.2,;-.5,11.69,;.19,9.11,;2.37,6.93,;2.77,8.42,)| Show InChI InChI=1S/C32H30FN9O3/c1-17(2)40-15-25(31(44)41(32(40)45)23-8-6-7-21(33)13-23)30(43)37-22-11-9-20(10-12-22)24-14-26(27-18(3)38-39(5)19(27)4)42-28(24)29(34)35-16-36-42/h6-17H,1-5H3,(H,37,43)(H2,34,35,36) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >100 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
US Patent
| Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ... |
US Patent US10844069 (2020)
BindingDB Entry DOI: 10.7270/Q2CZ3B73 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM397022
(US10442810, Example 84 | US10844069, Example 84 | ...)Show SMILES CC(C)n1cc(C(=O)Nc2ccc(cc2)-c2cc(-c3c(C)nn(C)c3C)n3ncnc(N)c23)c(=O)n(-c2cccc(F)c2)c1=O |(6.04,5.15,;4.95,6.24,;5.35,7.73,;3.46,5.84,;3.06,4.35,;1.57,3.96,;1.18,2.47,;2.27,1.38,;-.31,2.07,;-.71,.58,;.38,-.51,;-.02,-1.99,;-1.51,-2.39,;-2.6,-1.3,;-2.2,.18,;-1.91,-3.88,;-1,-5.13,;-1.91,-6.37,;-1.51,-7.86,;-.04,-8.34,;1.29,-7.57,;-.04,-9.88,;-1.51,-10.35,;-2.28,-11.69,;-2.41,-9.11,;-3.95,-9.11,;-3.37,-5.9,;-4.7,-6.67,;-6.04,-5.9,;-6.04,-4.36,;-4.7,-3.59,;-4.7,-2.05,;-3.37,-4.36,;.49,5.04,;-1,4.65,;.88,6.53,;-.2,7.62,;-1.69,7.22,;-2.78,8.31,;-2.38,9.8,;-.89,10.2,;-.5,11.69,;.19,9.11,;2.37,6.93,;2.77,8.42,)| Show InChI InChI=1S/C32H30FN9O3/c1-17(2)40-15-25(31(44)41(32(40)45)23-8-6-7-21(33)13-23)30(43)37-22-11-9-20(10-12-22)24-14-26(27-18(3)38-39(5)19(27)4)42-28(24)29(34)35-16-36-42/h6-17H,1-5H3,(H,37,43)(H2,34,35,36) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >100 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description
Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve... |
J Med Chem 52: 3576-85 (2009)
BindingDB Entry DOI: 10.7270/Q2FB5593 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM397022
(US10442810, Example 84 | US10844069, Example 84 | ...)Show SMILES CC(C)n1cc(C(=O)Nc2ccc(cc2)-c2cc(-c3c(C)nn(C)c3C)n3ncnc(N)c23)c(=O)n(-c2cccc(F)c2)c1=O |(6.04,5.15,;4.95,6.24,;5.35,7.73,;3.46,5.84,;3.06,4.35,;1.57,3.96,;1.18,2.47,;2.27,1.38,;-.31,2.07,;-.71,.58,;.38,-.51,;-.02,-1.99,;-1.51,-2.39,;-2.6,-1.3,;-2.2,.18,;-1.91,-3.88,;-1,-5.13,;-1.91,-6.37,;-1.51,-7.86,;-.04,-8.34,;1.29,-7.57,;-.04,-9.88,;-1.51,-10.35,;-2.28,-11.69,;-2.41,-9.11,;-3.95,-9.11,;-3.37,-5.9,;-4.7,-6.67,;-6.04,-5.9,;-6.04,-4.36,;-4.7,-3.59,;-4.7,-2.05,;-3.37,-4.36,;.49,5.04,;-1,4.65,;.88,6.53,;-.2,7.62,;-1.69,7.22,;-2.78,8.31,;-2.38,9.8,;-.89,10.2,;-.5,11.69,;.19,9.11,;2.37,6.93,;2.77,8.42,)| Show InChI InChI=1S/C32H30FN9O3/c1-17(2)40-15-25(31(44)41(32(40)45)23-8-6-7-21(33)13-23)30(43)37-22-11-9-20(10-12-22)24-14-26(27-18(3)38-39(5)19(27)4)42-28(24)29(34)35-16-36-42/h6-17H,1-5H3,(H,37,43)(H2,34,35,36) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >100 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
US Patent
| Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ... |
US Patent US10442810 (2019)
BindingDB Entry DOI: 10.7270/Q2NG4T17 |
More data for this
Ligand-Target Pair | |
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