Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase receptor TYRO3' and Ligand = 'BDBM397023'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM397023 (US10442810, Example 85 | US10844069, Example 85 | ...) Show SMILES CC(C)n1cc(C(=O)Nc2ccc(cc2)-c2cc(-c3cnc(cc3C)C(=O)N(C)C)n3ncnc(N)c23)c(=O)n(-c2ccccc2)c1=O Show InChI InChI=1S/C35H33N9O4/c1-20(2)42-18-27(33(46)43(35(42)48)24-9-7-6-8-10-24)32(45)40-23-13-11-22(12-14-23)25-16-29(44-30(25)31(36)38-19-39-44)26-17-37-28(15-21(26)3)34(47)41(4)5/h6-20H,1-5H3,(H,40,45)(H2,36,38,39)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MW2N2P
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM397023 (US10442810, Example 85 | US10844069, Example 85 | ...) Show SMILES CC(C)n1cc(C(=O)Nc2ccc(cc2)-c2cc(-c3cnc(cc3C)C(=O)N(C)C)n3ncnc(N)c23)c(=O)n(-c2ccccc2)c1=O Show InChI InChI=1S/C35H33N9O4/c1-20(2)42-18-27(33(46)43(35(42)48)24-9-7-6-8-10-24)32(45)40-23-13-11-22(12-14-23)25-16-29(44-30(25)31(36)38-19-39-44)26-17-37-28(15-21(26)3)34(47)41(4)5/h6-20H,1-5H3,(H,40,45)(H2,36,38,39)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM397023 (US10442810, Example 85 | US10844069, Example 85 | ...) Show SMILES CC(C)n1cc(C(=O)Nc2ccc(cc2)-c2cc(-c3cnc(cc3C)C(=O)N(C)C)n3ncnc(N)c23)c(=O)n(-c2ccccc2)c1=O Show InChI InChI=1S/C35H33N9O4/c1-20(2)42-18-27(33(46)43(35(42)48)24-9-7-6-8-10-24)32(45)40-23-13-11-22(12-14-23)25-16-29(44-30(25)31(36)38-19-39-44)26-17-37-28(15-21(26)3)34(47)41(4)5/h6-20H,1-5H3,(H,40,45)(H2,36,38,39)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM397023 (US10442810, Example 85 | US10844069, Example 85 | ...) Show SMILES CC(C)n1cc(C(=O)Nc2ccc(cc2)-c2cc(-c3cnc(cc3C)C(=O)N(C)C)n3ncnc(N)c23)c(=O)n(-c2ccccc2)c1=O Show InChI InChI=1S/C35H33N9O4/c1-20(2)42-18-27(33(46)43(35(42)48)24-9-7-6-8-10-24)32(45)40-23-13-11-22(12-14-23)25-16-29(44-30(25)31(36)38-19-39-44)26-17-37-28(15-21(26)3)34(47)41(4)5/h6-20H,1-5H3,(H,40,45)(H2,36,38,39)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair