Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase receptor TYRO3' and Ligand = 'BDBM397036'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM397036 (US10442810, Example 100 | US10844069, Example 100 ...) Show SMILES COc1ccn(-c2ccccc2)c(=O)c1C(=O)Nc1ccc(cc1)-c1c(Br)c(C2CCN(CC2)C(=O)C(C)C)n2ncnc(N)c12 Show InChI InChI=1S/C34H34BrN7O4/c1-20(2)33(44)40-16-13-22(14-17-40)29-28(35)26(30-31(36)37-19-38-42(29)30)21-9-11-23(12-10-21)39-32(43)27-25(46-3)15-18-41(34(27)45)24-7-5-4-6-8-24/h4-12,15,18-20,22H,13-14,16-17H2,1-3H3,(H,39,43)(H2,36,37,38)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MW2N2P
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM397036 (US10442810, Example 100 | US10844069, Example 100 ...) Show SMILES COc1ccn(-c2ccccc2)c(=O)c1C(=O)Nc1ccc(cc1)-c1c(Br)c(C2CCN(CC2)C(=O)C(C)C)n2ncnc(N)c12 Show InChI InChI=1S/C34H34BrN7O4/c1-20(2)33(44)40-16-13-22(14-17-40)29-28(35)26(30-31(36)37-19-38-42(29)30)21-9-11-23(12-10-21)39-32(43)27-25(46-3)15-18-41(34(27)45)24-7-5-4-6-8-24/h4-12,15,18-20,22H,13-14,16-17H2,1-3H3,(H,39,43)(H2,36,37,38)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM397036 (US10442810, Example 100 | US10844069, Example 100 ...) Show SMILES COc1ccn(-c2ccccc2)c(=O)c1C(=O)Nc1ccc(cc1)-c1c(Br)c(C2CCN(CC2)C(=O)C(C)C)n2ncnc(N)c12 Show InChI InChI=1S/C34H34BrN7O4/c1-20(2)33(44)40-16-13-22(14-17-40)29-28(35)26(30-31(36)37-19-38-42(29)30)21-9-11-23(12-10-21)39-32(43)27-25(46-3)15-18-41(34(27)45)24-7-5-4-6-8-24/h4-12,15,18-20,22H,13-14,16-17H2,1-3H3,(H,39,43)(H2,36,37,38)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM397036 (US10442810, Example 100 | US10844069, Example 100 ...) Show SMILES COc1ccn(-c2ccccc2)c(=O)c1C(=O)Nc1ccc(cc1)-c1c(Br)c(C2CCN(CC2)C(=O)C(C)C)n2ncnc(N)c12 Show InChI InChI=1S/C34H34BrN7O4/c1-20(2)33(44)40-16-13-22(14-17-40)29-28(35)26(30-31(36)37-19-38-42(29)30)21-9-11-23(12-10-21)39-32(43)27-25(46-3)15-18-41(34(27)45)24-7-5-4-6-8-24/h4-12,15,18-20,22H,13-14,16-17H2,1-3H3,(H,39,43)(H2,36,37,38)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair