Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase receptor TYRO3' and Ligand = 'BDBM397043'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM397043 (US10442810, Example 107 | US10844069, Example 107 ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cc(-c4cnn(C)c4)c(C)n(-c4ccccc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C38H39N9O3/c1-23(2)37(49)45-16-14-26(15-17-45)33-19-31(34-35(39)40-22-42-47(33)34)25-10-12-28(13-11-25)43-36(48)32-18-30(27-20-41-44(4)21-27)24(3)46(38(32)50)29-8-6-5-7-9-29/h5-13,18-23,26H,14-17H2,1-4H3,(H,43,48)(H2,39,40,42)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MW2N2P
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM397043 (US10442810, Example 107 | US10844069, Example 107 ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cc(-c4cnn(C)c4)c(C)n(-c4ccccc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C38H39N9O3/c1-23(2)37(49)45-16-14-26(15-17-45)33-19-31(34-35(39)40-22-42-47(33)34)25-10-12-28(13-11-25)43-36(48)32-18-30(27-20-41-44(4)21-27)24(3)46(38(32)50)29-8-6-5-7-9-29/h5-13,18-23,26H,14-17H2,1-4H3,(H,43,48)(H2,39,40,42)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM397043 (US10442810, Example 107 | US10844069, Example 107 ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cc(-c4cnn(C)c4)c(C)n(-c4ccccc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C38H39N9O3/c1-23(2)37(49)45-16-14-26(15-17-45)33-19-31(34-35(39)40-22-42-47(33)34)25-10-12-28(13-11-25)43-36(48)32-18-30(27-20-41-44(4)21-27)24(3)46(38(32)50)29-8-6-5-7-9-29/h5-13,18-23,26H,14-17H2,1-4H3,(H,43,48)(H2,39,40,42)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM397043 (US10442810, Example 107 | US10844069, Example 107 ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cc(-c4cnn(C)c4)c(C)n(-c4ccccc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C38H39N9O3/c1-23(2)37(49)45-16-14-26(15-17-45)33-19-31(34-35(39)40-22-42-47(33)34)25-10-12-28(13-11-25)43-36(48)32-18-30(27-20-41-44(4)21-27)24(3)46(38(32)50)29-8-6-5-7-9-29/h5-13,18-23,26H,14-17H2,1-4H3,(H,43,48)(H2,39,40,42)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair