Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase receptor TYRO3' and Ligand = 'BDBM397055'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM397055 (US10442810, Example 118 | US10844069, Example 118 ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cc(Br)c(C)n(-c4ccccn4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C33H33BrN8O3/c1-19(2)32(44)40-14-11-22(12-15-40)27-17-24(29-30(35)37-18-38-42(27)29)21-7-9-23(10-8-21)39-31(43)25-16-26(34)20(3)41(33(25)45)28-6-4-5-13-36-28/h4-10,13,16-19,22H,11-12,14-15H2,1-3H3,(H,39,43)(H2,35,37,38)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MW2N2P
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM397055 (US10442810, Example 118 | US10844069, Example 118 ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cc(Br)c(C)n(-c4ccccn4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C33H33BrN8O3/c1-19(2)32(44)40-14-11-22(12-15-40)27-17-24(29-30(35)37-18-38-42(27)29)21-7-9-23(10-8-21)39-31(43)25-16-26(34)20(3)41(33(25)45)28-6-4-5-13-36-28/h4-10,13,16-19,22H,11-12,14-15H2,1-3H3,(H,39,43)(H2,35,37,38)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM397055 (US10442810, Example 118 | US10844069, Example 118 ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cc(Br)c(C)n(-c4ccccn4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C33H33BrN8O3/c1-19(2)32(44)40-14-11-22(12-15-40)27-17-24(29-30(35)37-18-38-42(27)29)21-7-9-23(10-8-21)39-31(43)25-16-26(34)20(3)41(33(25)45)28-6-4-5-13-36-28/h4-10,13,16-19,22H,11-12,14-15H2,1-3H3,(H,39,43)(H2,35,37,38)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM397055 (US10442810, Example 118 | US10844069, Example 118 ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cc(Br)c(C)n(-c4ccccn4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C33H33BrN8O3/c1-19(2)32(44)40-14-11-22(12-15-40)27-17-24(29-30(35)37-18-38-42(27)29)21-7-9-23(10-8-21)39-31(43)25-16-26(34)20(3)41(33(25)45)28-6-4-5-13-36-28/h4-10,13,16-19,22H,11-12,14-15H2,1-3H3,(H,39,43)(H2,35,37,38)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair