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Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase receptor UFO' and Ligand = 'BDBM313081'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313081
PNG
(1-(2-chloro-7-methylthieno[3,2-d]pyrimidin-4-yl)-N...)
Show SMILES Cc1csc2c(nc(Cl)nc12)-n1nc(Nc2ccc(OCCN3CCCC3)cc2)nc1N
Show InChI InChI=1S/C21H23ClN8OS/c1-13-12-32-17-16(13)25-19(22)26-18(17)30-20(23)27-21(28-30)24-14-4-6-15(7-5-14)31-11-10-29-8-2-3-9-29/h4-7,12H,2-3,8-11H2,1H3,(H3,23,24,27,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2n/an/an/an/an/an/a



Rigel Pharmaceuticals, 1180 Veterans Blvd., South San Francisco, CA 94080, USA. Electronic address: dagoff@att.net.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human Axl (464 to 885 end residues) cytoplasmic domain expressed in baculovirus expression system using HS1 pepti...


Bioorg Med Chem Lett 27: 3766-3771 (2017)


Article DOI: 10.1016/j.bmcl.2017.06.071
BindingDB Entry DOI: 10.7270/Q26D5WH0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313081
PNG
(1-(2-chloro-7-methylthieno[3,2-d]pyrimidin-4-yl)-N...)
Show SMILES Cc1csc2c(nc(Cl)nc12)-n1nc(Nc2ccc(OCCN3CCCC3)cc2)nc1N
Show InChI InChI=1S/C21H23ClN8OS/c1-13-12-32-17-16(13)25-19(22)26-18(17)30-20(23)27-21(28-30)24-14-4-6-15(7-5-14)31-11-10-29-8-2-3-9-29/h4-7,12H,2-3,8-11H2,1H3,(H3,23,24,27,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...


US Patent US10166216 (2019)


BindingDB Entry DOI: 10.7270/Q21N836F
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM313081
PNG
(1-(2-chloro-7-methylthieno[3,2-d]pyrimidin-4-yl)-N...)
Show SMILES Cc1csc2c(nc(Cl)nc12)-n1nc(Nc2ccc(OCCN3CCCC3)cc2)nc1N
Show InChI InChI=1S/C21H23ClN8OS/c1-13-12-32-17-16(13)25-19(22)26-18(17)30-20(23)27-21(28-30)24-14-4-6-15(7-5-14)31-11-10-29-8-2-3-9-29/h4-7,12H,2-3,8-11H2,1H3,(H3,23,24,27,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 12n/an/an/an/a



Rigel Pharmaceuticals, 1180 Veterans Blvd., South San Francisco, CA 94080, USA. Electronic address: dagoff@att.net.

Curated by ChEMBL


Assay Description
Inhibition of Axl in human HeLa cells assessed as reduction in AKT phosphorylation at Ser 473 residues pre-incubated for 1 hr before preclustered ant...


Bioorg Med Chem Lett 27: 3766-3771 (2017)


Article DOI: 10.1016/j.bmcl.2017.06.071
BindingDB Entry DOI: 10.7270/Q26D5WH0
More data for this
Ligand-Target Pair