Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase receptor UFO' and Ligand = 'BDBM396998'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396998 (US10442810, Example 60 | US10844069, Example 60 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cc5C(=O)CCCc5n(-c5ccc(F)cc5)c4=O)cc3F)c12)C1CCN(CCO)CC1 Show InChI InChI=1S/C35H33F2N7O4/c36-21-4-7-23(8-5-21)43-29-2-1-3-31(46)26(29)17-27(35(43)48)34(47)41-22-6-9-24(28(37)16-22)25-18-30(44-32(25)33(38)39-19-40-44)20-10-12-42(13-11-20)14-15-45/h4-9,16-20,45H,1-3,10-15H2,(H,41,47)(H2,38,39,40)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396998 (US10442810, Example 60 | US10844069, Example 60 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cc5C(=O)CCCc5n(-c5ccc(F)cc5)c4=O)cc3F)c12)C1CCN(CCO)CC1 Show InChI InChI=1S/C35H33F2N7O4/c36-21-4-7-23(8-5-21)43-29-2-1-3-31(46)26(29)17-27(35(43)48)34(47)41-22-6-9-24(28(37)16-22)25-18-30(44-32(25)33(38)39-19-40-44)20-10-12-42(13-11-20)14-15-45/h4-9,16-20,45H,1-3,10-15H2,(H,41,47)(H2,38,39,40)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396998 (US10442810, Example 60 | US10844069, Example 60 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cc5C(=O)CCCc5n(-c5ccc(F)cc5)c4=O)cc3F)c12)C1CCN(CCO)CC1 Show InChI InChI=1S/C35H33F2N7O4/c36-21-4-7-23(8-5-21)43-29-2-1-3-31(46)26(29)17-27(35(43)48)34(47)41-22-6-9-24(28(37)16-22)25-18-30(44-32(25)33(38)39-19-40-44)20-10-12-42(13-11-20)14-15-45/h4-9,16-20,45H,1-3,10-15H2,(H,41,47)(H2,38,39,40)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396998 (US10442810, Example 60 | US10844069, Example 60 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cc5C(=O)CCCc5n(-c5ccc(F)cc5)c4=O)cc3F)c12)C1CCN(CCO)CC1 Show InChI InChI=1S/C35H33F2N7O4/c36-21-4-7-23(8-5-21)43-29-2-1-3-31(46)26(29)17-27(35(43)48)34(47)41-22-6-9-24(28(37)16-22)25-18-30(44-32(25)33(38)39-19-40-44)20-10-12-42(13-11-20)14-15-45/h4-9,16-20,45H,1-3,10-15H2,(H,41,47)(H2,38,39,40)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MW2N2P
					More data for this Ligand-Target Pair