Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase receptor UFO' and Ligand = 'BDBM397025'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM397025 (US10442810, Example 87 | US10844069, Example 87 | ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4cnn(C)c4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C33H38N10O4/c1-19(2)31(45)40-12-10-22(11-13-40)27-14-25(28-29(34)35-18-37-43(27)28)21-6-8-23(9-7-21)38-30(44)26-17-41(20(3)4)33(47)42(32(26)46)24-15-36-39(5)16-24/h6-9,14-20,22H,10-13H2,1-5H3,(H,38,44)(H2,34,35,37)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM397025 (US10442810, Example 87 | US10844069, Example 87 | ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4cnn(C)c4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C33H38N10O4/c1-19(2)31(45)40-12-10-22(11-13-40)27-14-25(28-29(34)35-18-37-43(27)28)21-6-8-23(9-7-21)38-30(44)26-17-41(20(3)4)33(47)42(32(26)46)24-15-36-39(5)16-24/h6-9,14-20,22H,10-13H2,1-5H3,(H,38,44)(H2,34,35,37)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM397025 (US10442810, Example 87 | US10844069, Example 87 | ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4cnn(C)c4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C33H38N10O4/c1-19(2)31(45)40-12-10-22(11-13-40)27-14-25(28-29(34)35-18-37-43(27)28)21-6-8-23(9-7-21)38-30(44)26-17-41(20(3)4)33(47)42(32(26)46)24-15-36-39(5)16-24/h6-9,14-20,22H,10-13H2,1-5H3,(H,38,44)(H2,34,35,37)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM397025 (US10442810, Example 87 | US10844069, Example 87 | ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4cnn(C)c4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C33H38N10O4/c1-19(2)31(45)40-12-10-22(11-13-40)27-14-25(28-29(34)35-18-37-43(27)28)21-6-8-23(9-7-21)38-30(44)26-17-41(20(3)4)33(47)42(32(26)46)24-15-36-39(5)16-24/h6-9,14-20,22H,10-13H2,1-5H3,(H,38,44)(H2,34,35,37)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MW2N2P
					More data for this Ligand-Target Pair