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Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase receptor UFO' and Ligand = 'BDBM50269381'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM50269381
PNG
(CHEMBL4100738)
Show SMILES [H][C@@]12CC[C@@]([H])(C1)[C@H](C2)N1CCN(CC1)c1ccc(Nc2nc(N)n(n2)-c2nc(Cl)nc3c(C)csc23)cc1Cl |r,THB:9:7:2.3:6|
Show InChI InChI=1S/C26H29Cl2N9S/c1-14-13-38-22-21(14)31-24(28)32-23(22)37-25(29)33-26(34-37)30-17-4-5-19(18(27)12-17)35-6-8-36(9-7-35)20-11-15-2-3-16(20)10-15/h4-5,12-13,15-16,20H,2-3,6-11H2,1H3,(H3,29,30,33,34)/t15-,16+,20+/m1/s1
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Similars
Article
PubMed
n/an/an/an/a 136n/an/an/an/a



Rigel Pharmaceuticals, 1180 Veterans Blvd., South San Francisco, CA 94080, USA. Electronic address: dagoff@att.net.

Curated by ChEMBL


Assay Description
Inhibition of Axl in human HeLa cells assessed as reduction in AKT phosphorylation at Ser 473 residues pre-incubated for 1 hr before preclustered ant...

Bioorg Med Chem Lett 27: 3766-3771 (2017)


Article DOI: 10.1016/j.bmcl.2017.06.071
BindingDB Entry DOI: 10.7270/Q26D5WH0
More data for this
Ligand-Target Pair