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Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase receptor UFO' and Ligand = 'BDBM50269385'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM50269385
PNG
(CHEMBL4098293)
Show SMILES Nc1nc(Nc2ccc(cc2)N2CCN(CC2)C2CC3CCC2C3)nn1-c1ncnc2ccsc12 |THB:14:17:20.21:23|
Show InChI InChI=1S/C25H29N9S/c26-24-30-25(31-34(24)23-22-20(7-12-35-22)27-15-28-23)29-18-3-5-19(6-4-18)32-8-10-33(11-9-32)21-14-16-1-2-17(21)13-16/h3-7,12,15-17,21H,1-2,8-11,13-14H2,(H3,26,29,30,31)
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Similars
Article
PubMed
n/an/an/an/a 21n/an/an/an/a



Rigel Pharmaceuticals, 1180 Veterans Blvd., South San Francisco, CA 94080, USA. Electronic address: dagoff@att.net.

Curated by ChEMBL


Assay Description
Inhibition of Axl in human HeLa cells assessed as reduction in AKT phosphorylation at Ser 473 residues pre-incubated for 1 hr before preclustered ant...

Bioorg Med Chem Lett 27: 3766-3771 (2017)


Article DOI: 10.1016/j.bmcl.2017.06.071
BindingDB Entry DOI: 10.7270/Q26D5WH0
More data for this
Ligand-Target Pair