Found 3 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein phosphatase non-receptor type 1' and Ligand = 'BDBM50142313' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human)) | BDBM50142313
![PNG](/data/jpeg/tenK5014/BindingDB_50142313.png) (2,2-Bis-[4-(difluoro-phosphono-methyl)-benzyl]-mal...)Show SMILES CC(C)OC(=O)C(Cc1ccc(cc1)C(F)(F)P(O)(O)=O)(Cc1ccc(cc1)C(F)(F)P(O)(O)=O)C(=O)OC(C)C Show InChI InChI=1S/C25H30F4O10P2/c1-15(2)38-21(30)23(22(31)39-16(3)4,13-17-5-9-19(10-6-17)24(26,27)40(32,33)34)14-18-7-11-20(12-8-18)25(28,29)41(35,36)37/h5-12,15-16H,13-14H2,1-4H3,(H2,32,33,34)(H2,35,36,37) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (docked) |
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human)) | BDBM50142313
![PNG](/data/jpeg/tenK5014/BindingDB_50142313.png) (2,2-Bis-[4-(difluoro-phosphono-methyl)-benzyl]-mal...)Show SMILES CC(C)OC(=O)C(Cc1ccc(cc1)C(F)(F)P(O)(O)=O)(Cc1ccc(cc1)C(F)(F)P(O)(O)=O)C(=O)OC(C)C Show InChI InChI=1S/C25H30F4O10P2/c1-15(2)38-21(30)23(22(31)39-16(3)4,13-17-5-9-19(10-6-17)24(26,27)40(32,33)34)14-18-7-11-20(12-8-18)25(28,29)41(35,36)37/h5-12,15-16H,13-14H2,1-4H3,(H2,32,33,34)(H2,35,36,37) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against CD45 protein-tyrosine phosphatase |
Bioorg Med Chem Lett 14: 1039-42 (2004)
Article DOI: 10.1016/j.bmcl.2003.11.048 BindingDB Entry DOI: 10.7270/Q28C9VPM |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (docked) |
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human)) | BDBM50142313
![PNG](/data/jpeg/tenK5014/BindingDB_50142313.png) (2,2-Bis-[4-(difluoro-phosphono-methyl)-benzyl]-mal...)Show SMILES CC(C)OC(=O)C(Cc1ccc(cc1)C(F)(F)P(O)(O)=O)(Cc1ccc(cc1)C(F)(F)P(O)(O)=O)C(=O)OC(C)C Show InChI InChI=1S/C25H30F4O10P2/c1-15(2)38-21(30)23(22(31)39-16(3)4,13-17-5-9-19(10-6-17)24(26,27)40(32,33)34)14-18-7-11-20(12-8-18)25(28,29)41(35,36)37/h5-12,15-16H,13-14H2,1-4H3,(H2,32,33,34)(H2,35,36,37) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.65E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against Protein tyrosine phosphatase 1B (PTP1B) overexpressed in intact Sf9 cell assay |
Bioorg Med Chem Lett 14: 1039-42 (2004)
Article DOI: 10.1016/j.bmcl.2003.11.048 BindingDB Entry DOI: 10.7270/Q28C9VPM |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (docked) |