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Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosyl-DNA phosphodiesterase 2' and Ligand = 'BDBM50521704'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosyl-DNA phosphodiesterase 2


(Homo sapiens (Human))		BDBM50521704
PNG
(CHEMBL4585941)
Show SMILES O=c1nc2n(-c3ccc(Oc4ccccc4)cc3)c3cc(ccc3cc2c(=O)[nH]1)C#N
Show InChI InChI=1S/C24H14N4O3/c25-14-15-6-7-16-13-20-22(26-24(30)27-23(20)29)28(21(16)12-15)17-8-10-19(11-9-17)31-18-4-2-1-3-5-18/h1-13H,(H,27,29,30)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.10E+3n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...

J Med Chem 62: 4669-4682 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00274
BindingDB Entry DOI: 10.7270/Q2F1934F
More data for this
Ligand-Target Pair