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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'U5 small nuclear ribonucleoprotein 200 kDa helicase' and Ligand = 'BDBM50260422'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
U5 small nuclear ribonucleoprotein 200 kDa helicase


(Homo sapiens (Human))		BDBM50260422
PNG
(CHEMBL4080080)
Show SMILES COC(=O)[C@@H]1C[C@H](CC(C)C)N(C(=O)c2c[nH]cn2)[C@@]11C(=O)Nc2ccc(F)cc12 |r|
Show InChI InChI=1S/C21H23FN4O4/c1-11(2)6-13-8-15(19(28)30-3)21(26(13)18(27)17-9-23-10-24-17)14-7-12(22)4-5-16(14)25-20(21)29/h4-5,7,9-11,13,15H,6,8H2,1-3H3,(H,23,24)(H,25,29)/t13-,15-,21+/m0/s1
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n/an/a 390n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...

Bioorg Med Chem 25: 4753-4767 (2017)


Article DOI: 10.1016/j.bmc.2017.07.017
BindingDB Entry DOI: 10.7270/Q27M0BDH
More data for this
Ligand-Target Pair