Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Ubiquitin-like modifier-activating enzyme ATG7 (Homo sapiens (Human)) | BDBM476001 (US10865208, Compound I-58 | {(2R,3S,4R,5R)-5-[4-am...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of recombinant His-tagged human ATG7 incubated for 105 mins in presence of GST-tagged ATG3 and Flag-tagged Gabarap and measured after 2 hr... | Citation and Details Article DOI: 10.1016/j.bmc.2020.115681 BindingDB Entry DOI: 10.7270/Q2M90DBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ubiquitin-like modifier-activating enzyme ATG7 (Homo sapiens (Human)) | BDBM476001 (US10865208, Compound I-58 | {(2R,3S,4R,5R)-5-[4-am...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <20 | n/a | n/a | n/a | n/a | n/a | n/a |
MILLENNIUM PHARMACEUTICALS, INC. US Patent | Assay Description The total volume of the ATG7 enzymatic assay is 50 μL and contains 50 mM HEPES Hemisodium (pH 7.5), 0.05% BSA, 0.01% Tween-20, 25 mM NaCl, 5 mM ... | US Patent US10865208 (2020) BindingDB Entry DOI: 10.7270/Q23B6366 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ubiquitin-like modifier-activating enzyme ATG7 (Homo sapiens (Human)) | BDBM476001 (US10865208, Compound I-58 | {(2R,3S,4R,5R)-5-[4-am...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 284 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of ATG7 in human 293HEK cells assessed as inhibition of ATG7:ATG8 thioester formation after 8 hrs by Western blot analysis | Citation and Details Article DOI: 10.1016/j.bmc.2020.115681 BindingDB Entry DOI: 10.7270/Q2M90DBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ubiquitin-like modifier-activating enzyme ATG7 (Homo sapiens (Human)) | BDBM476001 (US10865208, Compound I-58 | {(2R,3S,4R,5R)-5-[4-am...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of ATG7 in human 293HEK cells assessed as inhibition of ATG7:ATG8 thioester formation after 4 hrs by Western blot analysis | Citation and Details Article DOI: 10.1016/j.bmc.2020.115681 BindingDB Entry DOI: 10.7270/Q2M90DBR | |||||||||||
More data for this Ligand-Target Pair |