Found 2 hits Enz. Inhib. hit(s) with Target = 'Vascular endothelial growth factor receptor 2' and Ligand = 'BDBM50375193' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50375193
(CHEMBL269924)Show SMILES CC(C)Cn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(=O)c1sccc1Cl Show InChI InChI=1S/C29H25ClN4O2S/c1-14(2)12-34-22-7-4-15(27(35)28-20(30)8-9-37-28)10-17(22)24-18-11-31-29(36)25(18)23-16(26(24)34)5-6-21-19(23)13-33(3)32-21/h4,7-10,13-14H,5-6,11-12H2,1-3H3,(H,31,36) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Cephalon, Inc.
Curated by ChEMBL
| Assay Description Inhibition of VEGFR2 |
Bioorg Med Chem Lett 18: 2368-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.069 BindingDB Entry DOI: 10.7270/Q2ZG6T3P |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Mus musculus) | BDBM50375193
(CHEMBL269924)Show SMILES CC(C)Cn1c2ccc(cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12)C(=O)c1sccc1Cl Show InChI InChI=1S/C29H25ClN4O2S/c1-14(2)12-34-22-7-4-15(27(35)28-20(30)8-9-37-28)10-17(22)24-18-11-31-29(36)25(18)23-16(26(24)34)5-6-21-19(23)13-33(3)32-21/h4,7-10,13-14H,5-6,11-12H2,1-3H3,(H,31,36) | PDB MMDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Cephalon, Inc.
Curated by ChEMBL
| Assay Description Inhibition of mouse VEGFR2 autophosphorylation in NIH3T3 cell |
Bioorg Med Chem Lett 18: 2368-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.069 BindingDB Entry DOI: 10.7270/Q2ZG6T3P |
More data for this Ligand-Target Pair | |