BindingDB PrimarySearch

Found 2 hits Enz. Inhib. hit(s) with Target = 'Vitamin D3 receptor' and Ligand = 'BDBM50455853'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Vitamin D3 receptor (Homo sapiens (Human))	BDBM50455853 (CHEMBL4202828) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
University of Santiago de Compostela Curated by ChEMBL					Assay Description Displacement of fluormone from human full length VDR after 2 hrs by fluorescence polarization assay				J Med Chem 61: 4928-4937 (2018) Article DOI: 10.1021/acs.jmedchem.8b00337 BindingDB Entry DOI: 10.7270/Q22R3V8W
University of Santiago de Compostela Curated by ChEMBL					More data for this Ligand-Target Pair
Vitamin D3 receptor (Homo sapiens (Human))	BDBM50455853 (CHEMBL4202828) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	n/a	n/a	5.60	n/a	n/a	n/a	n/a
University of Santiago de Compostela Curated by ChEMBL					Assay Description Agonist activity at VDR in human MCF7 cells assessed as increase in transcription of CYP24A1 gene after 24 hrs by luciferase reporter gene assay				J Med Chem 61: 4928-4937 (2018) Article DOI: 10.1021/acs.jmedchem.8b00337 BindingDB Entry DOI: 10.7270/Q22R3V8W
University of Santiago de Compostela Curated by ChEMBL					More data for this Ligand-Target Pair