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Found 1 hit Enz. Inhib. hit(s) with Target = 'Voltage-dependent T-type calcium channel subunit alpha-1H' and Ligand = 'BDBM50461276'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))		BDBM50461276
PNG
(CHEMBL4227450)
Show SMILES OC(=O)C(F)(F)F.CN(C)CCCOc1ccc(CN(C)c2nc3ccc(Oc4ccc(cc4)C#N)cc3s2)cc1
Show InChI InChI=1S/C27H28N4O2S/c1-30(2)15-4-16-32-22-9-7-21(8-10-22)19-31(3)27-29-25-14-13-24(17-26(25)34-27)33-23-11-5-20(18-28)6-12-23/h5-14,17H,4,15-16,19H2,1-3H3
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Article
PubMed
n/an/a 6.40E+4n/an/an/an/an/an/a



IITB-Monash Research Academy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human Cav3.2-alpha1 expressed in HEK293T cells assessed as decrease in KCl-induced calcium mobilization measured after 600 ...

Bioorg Med Chem 26: 3046-3059 (2018)


Article DOI: 10.1016/j.bmc.2018.03.031
BindingDB Entry DOI: 10.7270/Q2BC4253
More data for this
Ligand-Target Pair