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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Voltage-dependent calcium channel gamma-8 subunit' and Ligand = 'BDBM50509857'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Voltage-dependent calcium channel gamma-8 subunit


(Rattus norvegicus)		BDBM50509857
PNG
(CHEMBL4474333)
Show SMILES Oc1ccc(cc1)-c1c(nc2c(nccn12)N1CCOCC1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H19ClN4O2/c23-17-5-1-15(2-6-17)19-20(16-3-7-18(28)8-4-16)27-10-9-24-21(22(27)25-19)26-11-13-29-14-12-26/h1-10,28H,11-14H2
PDB
MMDB

NCI pathway
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KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a<1.00E+4n/an/an/an/an/an/a



Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL


Assay Description
Negative allosteric modulation of TARPgamma8 in rat hippocampal neurons assessed as inhibition of glutamate-induced current at 10 uM at -60 mV holdin...

ACS Med Chem Lett 10: 267-272 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00599
BindingDB Entry DOI: 10.7270/Q26H4MRG
More data for this
Ligand-Target Pair