Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' and Ligand = 'BDBM124517'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM124517 (US8759532, 194) Show SMILES O[C@H]1CC[C@H](CC1)c1cccnc1Oc1ccc(cc1)C(=O)c1nc2ccccc2[nH]1 |r,wU:4.7,1.0,(-6.37,5.39,;-6.37,3.85,;-5.04,3.08,;-5.04,1.54,;-6.37,.77,;-7.71,1.54,;-7.71,3.08,;-6.37,-.77,;-7.71,-1.54,;-7.71,-3.08,;-6.37,-3.85,;-5.04,-3.08,;-5.04,-1.54,;-3.71,-.77,;-2.37,-1.54,;-2.37,-3.08,;-1.04,-3.85,;.29,-3.08,;.29,-1.54,;-1.04,-.77,;1.63,-3.85,;1.63,-5.39,;2.96,-3.08,;3.12,-1.55,;4.63,-1.23,;5.4,.11,;6.94,.11,;7.71,-1.23,;6.94,-2.56,;5.4,-2.56,;4.37,-3.71,)| Show InChI InChI=1S/C25H23N3O3/c29-18-11-7-16(8-12-18)20-4-3-15-26-25(20)31-19-13-9-17(10-14-19)23(30)24-27-21-5-1-2-6-22(21)28-24/h1-6,9-10,13-16,18,29H,7-8,11-12H2,(H,27,28)/t16-,18+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.308	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...				US Patent US8759532 (2014) BindingDB Entry DOI: 10.7270/Q25D8QHR
					More data for this Ligand-Target Pair