Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' and Ligand = 'BDBM124559'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM124559 (US8759532, 240) Show SMILES O=C(c1nc2ccccc2[nH]1)c1ccc(Oc2ncccc2C2CCCC(=O)CC2)cc1 Show InChI InChI=1S/C26H23N3O3/c30-19-6-3-5-17(10-13-19)21-7-4-16-27-26(21)32-20-14-11-18(12-15-20)24(31)25-28-22-8-1-2-9-23(22)29-25/h1-2,4,7-9,11-12,14-17H,3,5-6,10,13H2,(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0770	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...				US Patent US8759532 (2014) BindingDB Entry DOI: 10.7270/Q25D8QHR
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