Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' and Ligand = 'BDBM171916'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM171916 (US11419874, Example 8 | US9085584, 75) Show SMILES Cc1ccc(cc1-c1nnc2c(C)nc3ccc(nc3n12)C1CC1)C(C)(C)O Show InChI InChI=1S/C22H23N5O/c1-12-5-8-15(22(3,4)28)11-16(12)20-26-25-19-13(2)23-18-10-9-17(14-6-7-14)24-21(18)27(19)20/h5,8-11,14,28H,6-7H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Isolated cardiomyocytes were washed twice in PBS at room temperature, transferred to 4% paraformaldehyde (PFA) and gently shaken for 30 min, then was...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CR5XK9
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM171916 (US11419874, Example 8 | US9085584, 75) Show SMILES Cc1ccc(cc1-c1nnc2c(C)nc3ccc(nc3n12)C1CC1)C(C)(C)O Show InChI InChI=1S/C22H23N5O/c1-12-5-8-15(22(3,4)28)11-16(12)20-26-25-19-13(2)23-18-10-9-17(14-6-7-14)24-21(18)27(19)20/h5,8-11,14,28H,6-7H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The inhibition of PDE 2A or 10 enzyme activity was assessed using IMAP-Phosphodiesterase-cAMP fluorescence labeled substrate (Molecular Devices, Orde...				US Patent US9085584 (2015) BindingDB Entry DOI: 10.7270/Q27P8X54
					More data for this Ligand-Target Pair